By Micaela Morelli, Nicola Simola, Jadwiga Wardas
Adenosine A2A receptor antagonists have proven nice promise within the therapy of Parkinson's illness and relief of signs. This bookaddresses a variety of facets of this category of gear from their chemical improvement to their scientific use. among the insightful chapters contained during this booklet, there are 3 certain studies that experience now not formerly been released in any structure: (1) a heritage of istradefylline, the 1st A2A antagonist authorized for therapy of Parkinson's illness, (2) an summary of neuroimaging stories in human dying and disorder and (3) a examine of urate as a potential biomarker and neuroprotectant."
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Additional resources for The Adenosinergic System: A Non-Dopaminergic Target in Parkinson's Disease (Current Topics in Neurotoxicity)
Curr Top Med Chem 11:1034–1046 Squadrito F, Bitto A, Altavilla D et al (2014) The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabetic foot ulcers: results of a clinical trial. J Clin Endocrinol Metab 99:E746–E753 Storr M, Thammer J, Dunkel R et al (2002) Modulatory effect of adenosine receptors on the ascending and descending neural reflex responses of rat ileum. BMC Neurosci 3:21 Sullivan GW, Rieger JM, Scheld WM et al (2001) Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.
Am J Physiol Renal Physiol 290(4):F828–837 Baldwin SA, Beal PR, Yao SY et al (2004) The equilibrative nucleoside transporter family, SLC29. Pflugers Arch 447:735–743 Belardinelli L, Shryock JC, Snowdy S et al (1998) The A2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther 284:1066–1073 Biber K, Klotz KN, Berger M et al (1997) Adenosine A1 receptor-mediated activation of phospholipase C in cultured astrocytes depends on the level of receptor expression. J Neurosci 17:4956–4964 Bingham TC, Fisher EA, Parathath S et al (2010) A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux.
In fact, KW 6002 is already being successfully used in the treatment of Parkinson’s disease (Jenner 2014; Pinna 2014). The possibility of selectively targeting A1R-A2AR heteromers with SCH 442416 was used to identify an important contributor to the reinforcing effects of cannabinoids: cortico-striatal glutamatergic neurotransmission. Initially, a paradoxical result had ben reported, by which the A2AR antagonist MSX-3 decreases THC and anandamide self-administration in squirrel monkeys at a relatively low dose, while a three-fold higher dose produced the opposite effect (Justinová et al.