The Adenosinergic System: A Non-Dopaminergic Target in by Micaela Morelli, Nicola Simola, Jadwiga Wardas

By Micaela Morelli, Nicola Simola, Jadwiga Wardas

Adenosine A2A receptor antagonists have proven nice promise within the therapy of Parkinson's illness and relief of signs. This bookaddresses a variety of facets of this category of gear from their chemical improvement to their scientific use. among the insightful chapters contained during this booklet, there are 3 certain studies that experience now not formerly been released in any structure: (1) a heritage of istradefylline, the 1st A2A antagonist authorized for therapy of Parkinson's illness, (2) an summary of neuroimaging stories in human dying and disorder and (3) a examine of urate as a potential biomarker and neuroprotectant."

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Additional resources for The Adenosinergic System: A Non-Dopaminergic Target in Parkinson's Disease (Current Topics in Neurotoxicity)

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Curr Top Med Chem 11:1034–1046 Squadrito F, Bitto A, Altavilla D et al (2014) The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabetic foot ulcers: results of a clinical trial. J Clin Endocrinol Metab 99:E746–E753 Storr M, Thammer J, Dunkel R et al (2002) Modulatory effect of adenosine receptors on the ascending and descending neural reflex responses of rat ileum. BMC Neurosci 3:21 Sullivan GW, Rieger JM, Scheld WM et al (2001) Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.

Am J Physiol Renal Physiol 290(4):F828–837 Baldwin SA, Beal PR, Yao SY et al (2004) The equilibrative nucleoside transporter family, SLC29. Pflugers Arch 447:735–743 Belardinelli L, Shryock JC, Snowdy S et al (1998) The A2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther 284:1066–1073 Biber K, Klotz KN, Berger M et al (1997) Adenosine A1 receptor-mediated activation of phospholipase C in cultured astrocytes depends on the level of receptor expression. J Neurosci 17:4956–4964 Bingham TC, Fisher EA, Parathath S et al (2010) A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux.

In fact, KW 6002 is already being successfully used in the treatment of Parkinson’s disease (Jenner 2014; Pinna 2014). The possibility of selectively targeting A1R-A2AR heteromers with SCH 442416 was used to identify an important contributor to the reinforcing effects of cannabinoids: cortico-striatal glutamatergic neurotransmission. Initially, a paradoxical result had ben reported, by which the A2AR antagonist MSX-3 decreases THC and anandamide self-administration in squirrel monkeys at a relatively low dose, while a three-fold higher dose produced the opposite effect (Justinová et al.

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