Dopamine [Handbook of Chemical Neuroanatomy by S. Dunnett, et al.

By S. Dunnett, et al.

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Extra resources for Dopamine [Handbook of Chemical Neuroanatomy

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1980a). This study, which was 32 Dopamine circuits and receptors Ch. I based on sequential TH and CCK immunofluorescence, provided the first evidence of the coexistence of a neuropeptide with DA in neurons. By means of immunofluorescence analyzed in the adjacent sections incubated with antibodies to CCK and TH, respectively, in combination with fluorescent retrograde tracing, Ho¨kfelt and coworkers (1980b) could establish also the coexistence of TH and CCK in terminal fiber networks in the NAc and other targets of the mesolimbic system, and could determine that VTA neurons which contain both CCK and DA project to the caudal and medial portions of the NAc.

B and D are images of Nissl-stained sections. Abbreviations: CLI, central linear nucleus of the raphe; cpd, cerebral peduncle; DGlb, dentate gyrus, lateral blade; EW, Edinger-Westphal nucleus; fr, fasciculus retroflexus; hf, hippocampal fixure; IF, interfascicular 12 Dopamine circuits and receptors Ch. I and contains mostly medium-sized cells of various shapes resembling those of the SNc neurons. DA-containing neurons are concentrated in the SNc and are also found in the SNl (Figs. 4A, 7, 8). 2) but has also some distinct features of connectivity.

Fiber terminal networks containing substance P, enkephalin and dynorphin are densely distributed in the ventral midbrain tegmentum (reviewed by Fallon and Loughlin, 1985, 1995). Terminal fibers containing substance P and those containing dynorphin are very dense in the SNr, and more sparsely distributed in the VTA and SNc, whereas the terminal fibers containing enkephalin are concentrated in the SNc and in the dorsal portion of the VTA. These neuropeptides are coexpressed with GABA in subpopulations of striatal medium-sized spiny neurons, and therefore in subsets of the fibers which target the SN.

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