Clinical Functional MRI: Presurgical Functional Neuroimaging by Christoph Stippich

By Christoph Stippich

This is often the 1st textbook on scientific fMRI. it really is dedicated to preoperative fMRI in sufferers with mind tumors and epilepsies, that are the main well-established scientific functions. cutting-edge fMRI techniques are offered, with distinctive attention of the physiological and methodological heritage, imaging and knowledge processing, general and pathological findings, diagnostic probabilities and barriers, and different similar strategies.

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With these colours, a positive (negative) t value just passing a specified threshold would be colored in red (green), while a very high positive (negative) t value would be colored in yellow (blue) (Fig. 18). 000002 c Bonferroni corrected Fig. 18a–c. Comparison of two methods used to solve the multiple comparisons problem. A statistical map has been computed comparing responses to faces and houses. Red/yellow depict regions with larger responses to faces than to houses, while blue regions indicate areas with larger responses to houses than to faces.

During motion correction, for example, each functional volume of a run is aligned to a selected reference volume by adjusting rotation and translation parameters. The second view focuses on time courses of individual voxels (“voxel” = “volume element” analogous to “pixel” = picture element). This second view (Fig. 11b) helps to understand those preprocessing and statistical procedures, which process time courses of individual voxels. Most standard statistical analysis procedures operate in this way, including the General Linear Model (GLM).

In general, block and event-related designs can be statistically analyzed using the same mathematical principles (see Sect. 3). It is important to note that conventional fMRI data does not provide an absolute signal of brain activity limiting the quantitative interpretation of results. The major part of the signal amplitude is related to proton density and T2 tissue contrast varying across brain regions within and between subjects. BOLD related signal fluctuations, thus, have neither a defined origin nor a unit.

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