Chemical Architecture of the Nervous System by Donald B. Tower (auth.), Abel Lajtha (eds.)

By Donald B. Tower (auth.), Abel Lajtha (eds.)

Life, both as we predict of it within the summary in its optimum experience, or existence, as we predict of it when it comes to a compact residing organism, is clearly the results of advanced interplay of all the elements of the organism. you can hence query the advisability of setting apart out the worried method for a different specific examine in our age of overspecialization. the most goal of the current guide isn't really to fragment extra our technique or less than­ status of residing phenomena, yet, to the contrary, to aim to summarize and combine as a lot of the on hand details and pondering at the worried method as is feasible in a restricted area. it's tough to consider a space of contemporary biology that's extra interesting to check and that has larger impor­ tance for mankind, from any perspective, than the learn of the mind and of the frightened process. The effect that realizing of mind functionality in organic phrases can exert on our destiny isn't really usually understood in its complete impression. even if our lack of understanding approximately even the main uncomplicated mechanisms within the fearful method is big, in recent times our wisdom has made most crucial advances, and thus nice plenty of knowledge were accumulated.

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Eichelberger, The exchange of salt and water between muscle and blood. I. The effect of an increase in total body water prod uced by the intravenous injection of isotonic salt solution, J. Bioi. Chem. 117:73-93 (1937). 49. F. L. Truax (1954), cited in Ref. No. 16. 50. D. B. Tower, Distribution of cerebral fluids and electrolytes in vivo and in vitro, in Brain Edema (I. Klatzo and F. ), pp. 303-332, Springer-Verlag, New York (1967). ~ I. G. F. Bahr, G. Bloom, and U. Friberg, Volume changes of tissues in physiological fluids during fixation in osmium tetroxide or formaldehyde and during subsequent treatment, Exptl.

Woodbury, and L. Holtzer, Brain edema, electrolytes and extracellular space, Arch. Neurol. 10:604-614 (1964). 66. D. L. Woodward, D. J. Reed, and D. M. Woodbury, Extracellular space of rat cerebral cortex, Am. J. Physiol. 212:367-370 (1967). 67. D. P. Rail, W. W. Oppelt, and C. S. 2, 43--48 (1962). 22 Tower 68. I. M. Gibson and H. Mcilwain, Continuous recording of changes in membrane potential in mammalian cerebral tissues in vitro, 1. Physiol. (London) 176: 261-263 (1965). 69. B. Becker, Cerebrospinal fluid iodide, Am.

A. Epileptogenicity However, the majority of pathological problems relate more directly to failure of the "pump" systems and the consequent outward leakage and depletion of cellular K and its replacement by Na and Cl. 121) Presumably these abnormalities reflect impairment of operation of the Na and K transport systems in epileptogenic neurons, and it is suggested( 121) that the final common expression of epileptogenicity is likely to be such an impairment which creates the characteristic instability of the excitable membrane.

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