Case files neuroscience, Edition: Second edition by Jandial, Rahul; Neman, Josh; Snyder, Evan Y.; Toy, Eugene C

By Jandial, Rahul; Neman, Josh; Snyder, Evan Y.; Toy, Eugene C

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If resting channels were unopposed, the resting membrane potential would continue to decrease. Thus, there must be some mechanism to offset the continuous, slow leakage of Na+ and K+ ions across the membrane. The –65 mV resting membrane potential is maintained by the sodium-potassium pump, a large membranespanning protein with binding sites for Na+, K+, and ATP (Figure 3-1). The intracellular portion of the pump has binding sites for three Na+ ions. The extracellular portion contains two binding sites for K+ ions along with a portion for ATPase activity.

Kandel E, Schwartz J, Jessell T, eds. Principles of Neural Science. 5th ed. New York, NY: McGraw-Hill; 2012. Purves D, Augustine GJ, Fitzpatrick D, Hall WC, eds. Neuroscience. 5th ed. Sunderland, MA: Sinauer Associates Inc; 2011. indd 22 7/30/14 7:34 PM CASE 3 A 39-year-old man on business in Japan was brought to the emergency room (ER) by paramedics with initial complaints of numbness and tingling around the face and mouth. His symptoms progressed to include lightheadedness and nausea/ vomiting, which prompted the visit.

Four protofilaments combine to form the final neurofilament. Neurofilaments can form cross-links with microtubules to provide stiffness and shape to the cell. Within the context of Alzheimer disease, neurofilaments are modified to form pathological protein aggregates called neurofibrillary tangles. • Microfilaments are, as the name implies, the thinnest of the fiber types at approximately 3-5 nm in diameter and are formed by the polymerization of the protein actin to form a double helical structure.

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