Cannabinoids and the Brain by Attila Köfalvi

By Attila Köfalvi

Endocannabinoids have super healing capability. This e-book introduces readers to our present figuring out of the neurobiology of endocannabinoids and comparable structures, detailing their pathophysiological function and healing strength. Authors, skilled scientific investigators, current and research result of fresh medical trials in addition to the improvement of latest healing recommendations and medicines.

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2005); eBari et al. (2005); fOrtega-Gutiérrez et al. (2004); gFegley et al. (2004); hreviewed in Fowler et al. (2005); iDeutsch et al. (2001); jKaczocha et al. (2006); kThors and Fowler (2006); lRamakrishnan et al. (2002); mFowler et al. J. Fowler and L. Thors Fig. 2 Comparison of potencies for a series of AEA head group analogues (a) and a series of compounds with different primary structures (b) with respect to inhibition of FAAH and inhibition of AEA uptake. In (a), the data are taken from Jarrahian and colleagues (2000) and the inhibition of rat forebrain FAAH is compared with the inhibition of AEA uptake into rat cerebral granule cell cultures (2-min incubation period).

2007). , 2006). , 2007). Biochemical Consequences of FAAH Inhibition When considering the wide range of therapeutic possibilities afforded to FAAH inhibitors, it is important to remember that the enzyme is not restricted to the metabolism of AEA alone. , 2006). , 2006). , 2005, 2006). , 2006) (for further information see Chap. 9). A second issue concerns the potential for diverting AEA (and other N-acylethanolamine) metabolism from hydrolysis to production of other biologically active metabolites as a result of FAAH inhibition or genetic deletion.

Mechoulam R, Fride E, Di Marzo V (1998b) Endocannabinoids. Eur J Pharmacol 359:1–18. Melis M, Perra S, Muntoni AL, Pillolla G, Lutz B, Marsicano G, Di Marzo V, Gessa GL, Pistis M (2004) Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. J Neurosci 24:10707–10715. Moesgaard B, Petersen G, Jaroszewski JW, Hansen HS (2000) Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain. A 31P NMR and enzyme activity study.

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