Cancer. A Comprehensive Treatise: Volume 1. Etiology: by Peter C. Nowell (auth.), Frederick F. Becker (eds.)

By Peter C. Nowell (auth.), Frederick F. Becker (eds.)

This sequence of books makes an attempt to give, in a entire demeanour, the sector of oncology divided into 3 significant parts; etiology, biology, and remedy. those books may still function landmarks within the swiftly increasing experimental and scientific "universe" of this box. to a couple, they are going to be introductory; to others, a precis; for all, severe reviews at the futuI'e of analysis. In l'ecognition of the problems inherent in trying to pause and mirror whereas experimental facts emerge with ever-increasing rapidity, the shows take the shape of overviews instead of studies. the place attainable, an ancient viewpoint on observations and experimentation which ended in our current figuring out is gifted, the cutting-edge in method and procedure is reviewed, and the gaps in wisdom and in method are indicated. the purpose all through is integration-using the findings from one method for comparability with others. The super enlargement of curiosity in oncology as a medical-biological self-discipline motivated the e-book of those volumes. This enlargement, good warranted by way of the effect of oncology on human morbidity, has been characterised by way of at the very least 3 phenomena. First, there was a massive elevate in cash and manpower dedicated to the research and remedy of malignancy. That the learn has turn into increasingly more "directed" or program-oriented signs the curiosity of these past the clinical group within the administration of the eHort. moment, expanding numbers of scholars are getting into the sphere of oncology as their significant education program.

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45:815. , TOUGH, I. , AND WRIGHT, D. , 1963, Cytogenetic studies in Burkitt's lymphoma, Lancet 2: 1144. JENSEN, M. , 1970, Cytogenetic studies in potentially leukemic myeloid disorders, in: Proceedings of the XIII International Congress of Hematology, Munich, p. 20 (absL). JOHNSON, A. , FRIEDMAN, R. , 1971, Restoration of general morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine 3':5'-cyclic monophosphate and its derivatives, Proc. Natl. Acad. Sci. 68:425.

4. Animal Tumors Chromosome studies of tumors In animals have provided the opportunity to investigate in detail the relationship between cytogenetic change and various stages of neoplastic development. The results have generally paralleled the findings in man, but it has been possible with animal systems to study much more closely the very early steps in neoplastic transformation, both in vivo and in vitro, as well as later events in tumor progression. 1. Viral Tumors and Transformed Cells Only in animals can one investigate chromosome patterns in neoplasms known to be caused by oncogenic viruses, and the results indicate that a significant number 17 CYTOGENETICS 18 PETER C.

1967), and a missing metacentric chromosome in rat thyroid tumors produced by iodine depletion and repletion (Al-Saadi and Beierwaltes, 1967). Since it has not been possible, with repeated investigations, to demonstrate that a particular type of induced neoplasm in experimental animals is always or nearly always associated with a specific chromosome abnormality, it has remained difficult to assess the significance of these apparently nonrandom aberrations. 5. and rearrangements occur in human somatic cells in association with an increased incidence of cancer.

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