Apicomplexan Parasites: Molecular Approaches toward Targeted by Katja Becker, Paul M. Selzer

By Katja Becker, Paul M. Selzer

This guide is the 1st facing the invention of gear directed opposed to apicomplexan parasites. among others, this crew of endoparasites contains the causative brokers of Malaria, Toxoplasmosis, and Babesiosis, the latter happening mostly in animals. Written through popular medical specialists from academia and undefined, the ebook specializes in currentdrug improvement techniques for all apicomplexan ailments making it attractive to a wide viewers, starting from study labs in academia to the human and veterinarian pharmaceutical undefined. This paintings is the second one quantity of the hot e-book sequence 'Drug Discovery in Infectious Diseases', edited by means of Prof. Dr Paul M. Selzer.

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34, 1166–1173. , Hiranuka, K. et al. (2009) Full-Malaria/ Parasites and Full-Arthropods: databases of full-length cDNAs of parasites and arthropods, update 2009. , 37, D520–D525. , Ivanova, N. et al. (2005) The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode. , 3, e121. H. (2003) Glutathionefunctions and metabolism in the malarial parasite Plasmodium falciparum. Biol. , 384, 551–566. j33 j35 3 Sorting Potential Therapeutic Targets in Apicomplexa Jan A.

2009) Next-generation DNA sequencing techniques. Nat. , 25, 195–203. K. (2008) Single-molecule DNA sequencing technologies for future genomics research. , 26, 602–611. A. (2009) Advances in parasite genomics: from sequences to j17 j 1 Drug Discovery Approaches Toward Anti-Parasitic Agents 18 34 35 36 37 38 39 40 41 42 43 regulatory networks. , 5, e1000649. C. (2008) The Genomes OnLine Database (GOLD) in 2007: status of genomic and metagenomic projects and their associated metadata. , 36 (Database issue), D475–D479.

The example [44] shown is the central redox network around glutathione reductase (GR) and reduced glutathione (GSH). The flow (light blue ¼ major metabolic flow, black arrows ¼ further connected processes, simplified) through these networks can be calculated (key enzymes and substrates are shown in blue), and thus also complex and broad effects of different drugs appropriately modeled; for instance, methylene blue would affect several of the involved enzymes and centrally target GR (middle). This also occurs in the host (human GR) and by Synthesis of DNA methylene blue acting as a subversive substrate, incapacitating the enzymes that metabolize it.

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