Aging and Cell Structure: Volume 2 by Robert O. Kelley, Kathryn G. Vogel (auth.), John E. Johnson

By Robert O. Kelley, Kathryn G. Vogel (auth.), John E. Johnson Jr. (eds.)

Although millions of articles and 1000s of books on getting older were released, just a small percent of this fabric has handled anatomy, quite on the advantageous­ structural point. It used to be with this in brain that getting older and telephone constitution was once conceived. quantity 1 of getting older and mobile constitution was once released in 1981 and represented a present compilation of data, concentrating on the electron microscopic point, on morphological adjustments which take place in cells and tissues as they age. the current quantity completes the two-volume set. whereas quantity 1 highlighted structural alterations taking place within the getting older anxious approach, quantity 2 facilities its efforts on stories of in vitro getting older. Chapters on different matters are incorporated in addition. those comprise age-related adjustments noticeable in neuromuscular junctions, oral tissues, and the pancreas. even supposing those volumes signify a truly small a part of the broadcast infor­ mation on experimental gerontology, their strategy is quite targeted simply because they concentrate on anatomy, maybe the main simple of the entire biomedical sciences. simply because many dif­ ferent tissue forms are tested, we start to determine recurrent, definitive styles within the getting older mobilephone which can now not be absolutely obvious from experiences taking one mobile kind at a time. This turns into much more glaring within the current quantity the place alterations obvious in popula­ tions of cells grown in culture-isolated from hormones or apprehensive impulses from different physique areas-are came upon to be just like these alterations present in vivo.

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Extra resources for Aging and Cell Structure: Volume 2

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1976, Age-related alterations in plasma membrane glycoprotein content and scheduled or unscheduled DNA synthesis, Arch. Biochem. Biophys. 176:324. , and Schneider, E. , 1976a, Increased nuclear sizes in senescent human fibroblast cultures, Exp. Cell Res. 100:147. , and Schneider, E. , 1976b, Relationship between cell replication and volume in senescent human diploid fibroblasts, Mech. Ageing Devl. 5:45. , and Schneider, E. , 1976c, Characterization of fractionated human diplid fibroblast cell populations, Exp.

1974, Structure and function of intercellular junctions, Int. Rev. Cytol. 39:191. Steck, T. , 1974, The organization of proteins in the human red blood cell membrane: A review, J. Cell Bioi. 62:1. Stein, G. , and Yanishevsky, R. , 1979, Entry into S phase is inhibited in two immortal cell lines fused to senescent human diploid cells, Exp. Cell Res. 120:155. , 1977, Changes in the distribution of a major fibroblast protein fibronectin, during mitosis and interphase, J. Cell Bioi. 74:453. Stewart, C.

A great deal of chromatin condensation can be seen in the nucleus (N) of this 49 POL IMR-90 fibroblast. The cytoplasm contains shortened segments of granular endoplasmic reticulum. Regions of ribosome-covered (solid arrow with no dot) as well as denuded (solid arrow with one dot) reticulum are present. The inset shows this phenomenon at higher magnification. Main figure X 19,200; inset X 38,000, reproduced at 85%. ) 45 Figure 7. A neuronal nuclear inclusion is shown from the frontal cortex of a seven-year-old squirrel monkey.

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