2011-2012 Basic and Clinical Science Course, Section 9: by Ramana S. Moorthy MD

By Ramana S. Moorthy MD

Starts with an in-depth evaluation of immunemedicated eye sickness, summarizing uncomplicated immunologic thoughts, ocular immune responses and unique subject matters in ocular immunology. Discusses the medical method of uveitis and experiences noninfectious (autoimmune) and infectious varieties of uveitis, with an multiplied part on viral uveitis and new fabric on infectious and noninfectious scleritis. superior detection of infectious brokers by means of immunologic and genetic tools and new biologic therapeutics are distinctive. additionally covers endophthalmitis, masquerade syndromes, problems of uveitis and ocular features of AIDS. incorporates a variety of new colour pictures. significant revision 2011-2012

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Extra info for 2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course)

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PAF antagonists are being developed and tested in clinical trials. Synergistic interactions probably exist among PAFs, nitric oxide, eicosanoids, and cytokines. Intravitreal injection of PAFs in an imals induces an acute retinitis. The precise role ofPAFs in intraocular inflammation remains unknown. Cytokines Cytokines are soluble polypeptide mediators that are synthesized and released by cells for the purposes of intercellular signaling and commun ication. Table 1-3 lists some examples of cytokines that are associated with ocular inflammation .

As well as many other sites that remain invisible to the immune system. The term paratope refers to the epitope-specific binding site on the Fab (fragment. antigen-binding) portion of the antibody. In addition. antigenic proteins can be enzymatically digested into many different peptide fragments by APCs. some of which then serve as antigenic epitopes for T lymphocytes. Afferent lymphatic channels Also simply called lymphatics. afferent lymphatic channels are veinlike structures that drain extracellular fluid (ie.

Role of regulatory T lymphocytes The immunoregulatory role of regulatory (or suppressor) T lymphocytes has become partially clarified, especially through the induction of immunomodulatory cytokine synthesis by regulatory T lymphocytes. Originally, regulatory T lymphocytes were thought to express the CDS marker and to become activated during the initial phases of processing. More recently, Treg CD4+ CD25+ Foxp3+ T lymphocytes have also been observed to have regulatory functions. In many cases, both CDS and CD4 regulatory T lymphocytes appear to operate by the release of immunomodulatory cytokines such as transforming growth factor ~, which can inhibit or alter the effector function of other T lymphocytes.

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