By Robert H. Rosa Jr., MD
This quantity is split into elements: half I, Ophthalmic Pathology; and half II, Intraocular Tumors: medical points. half I makes use of a hierarchy that strikes from basic to express to aid derive a differential prognosis for a selected tissue. half II is a compilation of chosen scientific facets of value to the overall ophthalmologist. Following half II are the yankee Joint Committee on melanoma 2010 staging varieties for ocular and adnexal tumors. This revised textual content includes a number of new pathologic and scientific images. significant revision 2011-2012.
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Extra resources for 2011-2012 Basic and Clinical Science Course, Section 4: Ophthalmic Pathology and Intraocular Tumors (Basic & Clinical Science Course)
Molecular Pathology Molecular biology techniques are used increasingly in diagnostic ophthalmiC pathology and extensively in experimental pathology (Table 4-2). More recentl y, their use has expanded to include prognostication of disease and determination of treatment. Molecular path olog y is used to identify tumor-promoting or tumor-inhibiting genes (CGH, PCR, array CGH ), such as the retinoblastoma gene; and viral DNA or RNA strands, such as those seen in herpesviruses and Epstein-Barr virus (PCR, in situ hybridization [ISH ]) .
Parr A counesyof AnthonyJ Lubmewski. MO; parr B courtesy of George J Harocopos. MDJ 54 • Ophthalmic Pathology and Int raocular Tum ors result ing in ulcers in herpetic disease (see Chapte r 6) and subepithelial infiltrates in adenoviral disease. Specific diagnosis of infectious conjunctivitis may be made based on clinical history and examination (typically sufficient for viral disease), or it may require Gram stain/cuiture, PCR, or serology, depend ing on the organism.
Courtesy of Hans E. Grossniklaus. ) Rupture of the Bruch membrane or choroidal rupture may occur after direct or indirect injury to the globe. Choroidal neovascularization, granulation tissue proliferation, and scar formation may occur in an area of choroidal rupture. A subset of direct choroidal ruptures, those usually occurring after a projectile injury, may result in focal posttraumatic choroidal granulomatous inflammation (Fig 2-10). This may be related to foreign material introduced into the choroid.